- Kallmann's Syndrome Associasted with Slipped Capital Femoral Epiphysis.
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Hyeon Jeong Jeon, Byeong Seong Ko, Do Hyeong Kim, Jang Hwan Bae, TGae Geun Oh, Seung Baek Kang
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J Korean Endocr Soc. 1996;11(3):318-323. Published online November 7, 2019
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- The Kallmanns syndrome is the most common form of isolated hypogonadotropic hypogonadism in which anosmia or hyposmia resulting from agenesis of hypoplasia of the olfactory lobes is associated with LHRH deficiency, This syndrome is genetically heterogeneous and can be trans-mitted as an X-linked, autosomal dominant or autosomal recessive trait. The hypogonadotropic hypogonadism results in absent or incomplete pubertal development and may be associated with anosmia or hyposmia, mid-line defect(color blindness, cleft-lip or -palate, unilateral renal agenesis, nerve deafness), cryptorchidism and skeletal abnormalities. The slipped capital fernoral epiphysis is the condition in which the femoral head slips downward and backward on the femoral neck at the epiphyseal plate. The clinical association between slipped capital femoral epiphysis and endocrine disorder. We experienced a case of the slipped capital femoral epiphyis associated with Kallmanns syndrome in a 17 years old male.
- A Korean Pedigree of Paget Bone Disease: Including a Case of Panostotic Paget Bone Disease complicated with Giant Cell Reparative Granuloma.
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Eui Tae Jeong, Jae Hong Park, Do Hyeong Kim, Byoung Oh Jeong, Kyung Soo Ko, Byoung Doo Rhee
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J Korean Endocr Soc. 1995;10(4):456-466. Published online November 7, 2019
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Abstract
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- The polyglandular autoimmune syndrome designates the dysfunction of endocrine and nonendocrine system involving two or more organs on the basis of an autoimmune mechanism. The autoimmune nature of these diseases has been based on the presence of lymphocytic infiltration in the affected gland, organ specific autoantibodies in the serum, cellular immune defects and an association with the HLA DR/DQ genes or immune response genes. This syndrome is usually classified into three classes and their etiology or pathogenesis is still not completely understood. A 28-year-old woman developed vitiligo and insulin dependent diabetes mellitus during the treatment of Graves' disease with antithyroid drug. She had a tendency of spontaneous ketonemia and serum c-peptide levels were low(0.21, 0.16ng/mL: fasting and glucagon stimulated). Thyrotrophin binding inhibitor immunoglobulin and pancreas iIslet cell cytoplasmic antibody were positive. We report here a case of polyglandular autoimmune syndrome, type III manifesting Graves' disease, vitiligo, and insulin dependent diabetes mellitus.
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